CEBPE

CCAAT/enhancer binding protein (C/EBP), epsilon
Identifiers
Symbols CEBPE; C/EBP-epsilon; CRP1
External IDs OMIM: 600749 MGI: 103572 HomoloGene: 1367 GeneCards: CEBPE Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 1053 110794
Ensembl ENSG00000092067 ENSMUSG00000052435
UniProt Q15744 Q32MW8
RefSeq (mRNA) NM_001805 NM_207131.1
RefSeq (protein) NP_001796 NP_997014.1
Location (UCSC) Chr 14:
23.59 – 23.59 Mb		 Chr 14:
55.33 – 55.33 Mb
PubMed search [1] [2]

CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CHOP, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene.[1][2] It is pro-apoptotic.[3]

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.[1]

References

  1. ^ a b "Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1053. 
  2. ^ Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (July 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics 35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID 8661101. 
  3. ^ Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M (May 2006). "N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation". J. Biol. Chem. 281 (20): 14494–502. doi:10.1074/jbc.M600575200. PMID 16531405. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.